The role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases - PubMed
3 hours ago
- #therapeutic target
- #digestive diseases
- #MANF
- MANF is an evolutionarily conserved protein highly expressed in the digestive system.
- MANF plays dual roles in liver diseases, acting protectively in some conditions (e.g., ALD, MASLD) and promoting disease in others (e.g., HBV infection, ICC).
- In pancreatic disorders, MANF protects β-cells from ER stress-induced apoptosis in diabetes and mitigates acute pancreatitis.
- MANF ameliorates inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC) in intestinal diseases.
- MANF's functions are determined by cellular context, disease stage, and microenvironmental signals.
- Targeting MANF may represent a potential therapeutic strategy for digestive diseases, and its dynamic expression suggests biomarker utility.