RNA polymerase II drives FUS and EWSR1 exclusion from damaged chromatin - PubMed
4 hours ago
- #DNA repair
- #RNA polymerase II
- #FUS/EWSR1 exclusion
- RNA polymerase II (via its subunit RPB1) and transcription-associated kinases (CDK7, CDK9, CDK12/13) drive the exclusion of FUS and EWSR1 from complex DNA damage sites.
- Inhibition of these kinases or depletion of RPB1 prevents the exclusion of FUS and EWSR1, indicating their role in this process.
- CDK7 inhibition also reduces the accumulation of the DNA repair protein 53BP1 at lesions, linking transcription machinery to DNA repair coordination.