Gut pathogen Clostridium symbiosum rewires macrophage succinylation to drive enteric neuron loss in inflammatory bowel disease - PubMed
4 hours ago
- #Neuron loss
- #IBD
- #Clostridium symbiosum
- Clostridium symbiosum, a gut pathogen, exacerbates enteric neuron loss and colitis in inflammatory bowel disease (IBD).
- C. symbiosum-derived succinate drives macrophage glycolysis via the H3K79succ/HK2 axis, sustaining IL-1β secretion and promoting neuronal NLRP3 inflammasome activation.
- Preventing enteric neuron loss improves outcomes in C. symbiosum-exacerbated colitis.
- Endolysin phiCS-1, derived from C. symbiosum-specific bacteriophages, effectively lyses the pathogen and reduces neuron loss and colitis.
- The study highlights the role of gut microbiota in immune-neuron interactions and suggests potential therapeutic targets for IBD.