Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response - PubMed
4 hours ago
- #tRNA modification
- #melanoma
- #immune response
- Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.
- OSGEP, which catalyzes tRNA modification t6A, maintains T-cell exclusion and prevents anti-tumour immune response in melanoma.
- t6A-deficient melanoma cells disrupt translation of ANN codons, leading to protein aggregation and stress granule formation.
- OSGEP loss activates RIG-I pathway, recruiting T-cells and inducing anti-tumour immune response.
- An OSGEP-driven gene signature in melanoma patients correlates with T-cell infiltration and improved survival.
- t6A tRNA modification is identified as a potential therapeutic target for melanoma treatment.