CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters - PubMed
3 days ago
- #MRSA
- #antimicrobial peptides
- #artificial intelligence
- CAMPER is a mechanistic AI framework for designing antimicrobial peptides targeting MRSA persisters.
- It integrates machine learning and biophysical ranking to prioritize effective peptides.
- WP-CAMPER1, a 12mer peptide, shows potent activity against S. aureus MW2 with a MIC of 4 µg/mL.
- Topical WP-CAMPER1 reduces S. aureus burden by 2.5 log10 in a murine skin infection model.
- The D-enantiomer, WP-CAMPER1-d, reduces biofilm infections by 1.37 log10.
- Single-cell analysis shows WP-CAMPER1-d reduces persisters in S. aureus USA300.
- In a deep-seated thigh infection model, WP-CAMPER1-d decreases stationary-phase persisters by 1.6 log10.
- The study highlights the potential of AI-driven peptide design to combat antibiotic resistance.