Oncogenic GPRIN1 sustains proliferation and mitochondrial homeostasis via dual‑layer CDK1-PI3K/Akt signalling in gallbladder cancer - PubMed
3 hours ago
- #CDK1-PI3K/Akt signaling
- #gallbladder cancer
- #GPRIN1
- GPRIN1 is significantly upregulated in gallbladder cancer (GBC) tissues and correlates with advanced clinical stage and poor prognosis.
- GPRIN1 drives cell cycle progression and maintains mitochondrial homeostasis in GBC.
- GPRIN1 activates CDK1 through dual mechanisms: transcriptional co-activation with E2F1 and post-translational regulation by steering CDK1 away from its inhibitor MYT1 toward its activator Cdc25C.
- Hyperactivated CDK1 unleashes PI3K-Akt signaling, coupling cell proliferation with mitochondrial support.
- Disruption of the GPRIN1-CDK1-PI3K/Akt axis abrogates tumorigenesis in vitro and in vivo.
- Targeting GPRIN1 may represent a specific therapeutic strategy for GBC.