A two-step scoring model incorporating visceral-to-subcutaneous fat ratio and systemic immunoinflammatory index for predicting cytokine release syndrome severity in patients with gastric cancer receiv
12 hours ago
- #CAR-T cell therapy
- #Gastric cancer
- #Cytokine release syndrome
- A two-step scoring model predicts cytokine release syndrome (CRS) severity in gastric cancer patients undergoing Claudin18.2-targeted CAR-T cell therapy.
- The model uses visceral-to-subcutaneous fat ratio (VSR) and systemic immunoinflammatory index (SII) as key predictors.
- Patients with CRS grade 2 had significantly higher VSR and SII compared to those with grade 1.
- The area under the curve (AUC) for VSR and SII in predicting CRS grade was 0.762 and 0.721, respectively.
- A VSR ≥ 0.21 and SII > 553 × 109/L were significantly associated with high-grade CRS.
- The combined two-step model achieved an AUC of 0.802 for predicting high-grade CRS.
- The study provides a practical tool for early risk stratification and clinical intervention.