Predictive value of BMD for hip and other fractures: a meta-analysis to update FRAX - PubMed
7 hours ago
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- Meta-analysis of 307,205 men and women from 53 cohort studies to determine the relationship between femoral neck BMD and fracture risk.
- Low BMD is a significant predictor of fracture risk, especially for hip fractures.
- 73% of hip fractures in men and 92% in women occurred in those with low bone mass or osteoporosis at baseline.
- BMD at the femoral neck strongly predicts hip fractures with similar gradient of risk (GR) in men and women.
- GR for hip fractures decreases with age but remains significant.
- GR for major osteoporotic fractures (MOF) remains stable with age.
- Predictive value of BMD varies with age, sex, follow-up duration, and initial BMD value.
- Femoral neck BMD is crucial for fracture risk assessment, particularly for hip fractures.
- Non-skeletal factors contribute to hip fracture risk with advancing age.
- Study supports the use of BMD in case-finding strategies but highlights the need to consider variations in predictive value.