CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination - PubMed
4 hours ago
- #ROBO2
- #Glioblastoma
- #CD47
- CD47 is highly expressed at the invasive edge of glioblastoma (GBM) tumors and correlates with poor patient survival.
- CD47 loss impairs GBM cell proliferation, migration, and invasion, independent of immune activity, leading to reduced tumor burden and prolonged survival in vivo.
- ROBO2 signaling is identified as a key downstream effector of CD47, with loss of ROBO2 similarly reducing GBM cell proliferation and migration.
- CD47 stabilizes ROBO2 by sequestering the E3 ubiquitin ligase ITCH, preventing ubiquitination and proteasomal degradation of ROBO2.
- The study highlights the therapeutic potential of targeting CD47-ROBO2 signaling in GBM.