PRSS22 inhibits HMOX1-mediated ferroptosis and induces osteopontin cleavage to promote M2 macrophage polarization and colitis-associated carcinogenesis - PubMed
5 hours ago
- #ferroptosis
- #colorectal cancer
- #PRSS22
- PRSS22 is identified as a key driver of inflammation-cancer transition (ICT) in colorectal cancer (CRC).
- PRSS22 expression correlates with the pathological progression of colitis-associated ICT.
- Genetic disabling of PRSS22 inhibits CRC cell growth, migration, and causes redox stress.
- Knocking down PRSS22 promotes HMOX1 expression, leading to ferroptosis and fine-tuning inflammatory response.
- Loss of PRSS22 prevents osteopontin cleavage, reducing CRC cell migratory capacity.
- PRSS22 knockdown reduces M0-to-M2 macrophage polarization in co-culture systems.
- Targeting PRSS22 is suggested as a promising therapeutic strategy against CRC.