FGF family in health and disease - PubMed
4 hours ago
- #Metabolic homeostasis
- #FGF signaling
- #Therapeutic targets
- Fibroblast growth factors (FGFs) are evolutionarily conserved signaling molecules crucial for embryonic patterning, tissue regeneration, and metabolic homeostasis.
- FGFs interact with fibroblast growth factor receptors (FGFRs) and cofactors to regulate cellular fate and interorgan communication.
- Canonical FGFs manage local tissue dynamics, while endocrine FGFs (FGF19, FGF21, FGF23) act as systemic hormones regulating bile acid, glucose, and phosphate metabolism.
- The review covers FGF classification, structural features, receptor specificity, and signaling pathways, including canonical and non-canonical mechanisms.
- Regulation of FGF signaling involves heparan sulfate proteoglycans, Klotho coreceptors, and intracellular feedback mechanisms.
- FGFs play roles in organ development, tissue repair, metabolic regulation, and disease pathogenesis.
- Therapeutic strategies targeting the FGF axis include agonism for regeneration and metabolic regulation, and antagonism to block oncogenic signaling in cancer.