Desmin mutations in cardiomyocytes increase susceptibility to coxsackievirus B3 infection by impairing antiviral IFN-β response and upregulating viral receptors expression - PubMed
3 hours ago
- #cardiomyopathy
- #genetic mutation
- #viral infection
- Desmin mutations in cardiomyocytes increase susceptibility to Coxsackievirus B3 (CVB3) infection.
- Mutations impair antiviral IFN-β response and upregulate viral receptors (CAR and cell-surface vimentin).
- Human iPSC-derived cardiomyocytes (hiPSC-CMs) with DES mutations show enhanced viral replication and reduced contractility.
- CVB3 infection worsens structural disorganization and desmin aggregation in mutation-specific ways.
- Study reveals a pathogenic synergy between genetic cytoskeletal defects and viral infection in cardiac dysfunction.