Copper supports regulatory T cell energetic state to sustain peripheral immune tolerance - PubMed
19 hours ago
- #Copper metabolism
- #Autoimmune diseases
- #Regulatory T cells
- Treg cells with a high energetic state show enhanced suppressive function.
- Copper chelators and ionophores were identified as modulators of Treg cell energetic state via a mitochondrial inhibitor screen.
- TCR stimulation and autoimmune conditions increase labile copper in Treg cells.
- Slc31a1, a copper transporter in murine Treg cells, supports oxidative phosphorylation, NAD+/NADH homeostasis, and histone acetylation.
- Copper metabolism ensures energy production and Treg cell functionality, critical for peripheral immune tolerance.
- The copper ionophore elesclomol can rescue Treg cell function, suggesting therapeutic potential for autoimmune diseases.