A mechanism to initiate emergency type 2 myelopoiesis - PubMed
a day ago
- #immunology
- #myelopoiesis
- #parasite infection
- Immune responses to parasite infection increase production of basophils and eosinophils, crucial for type 2 anti-parasite immunity.
- Infection with Heligmosomoides polygyrus shifts erythroid-primed multipotent progenitors (EMPPs) from erythropoiesis to myeloid fate.
- IL-33 alarmin accumulates in bone marrow during infection, upregulating LMO4 in EMPPs, promoting myeloid differentiation.
- LMO4 interacts with GATA2, displacing FOG1 and redistributing GATA binding to basophil, eosinophil, and mast cell (BEM)-specific chromatin.
- Mice with a GATA2 mutation impairing LMO4-GATA2 interaction show deficient myeloid lineage commitment and parasite control.
- LMO4 is identified as an IL-33-regulated master regulator of type 2 myelopoiesis.