Thymic health and immunotherapy outcomes in patients with cancer - PubMed
3 hours ago
- #immunotherapy
- #thymus
- #cancer
- Thymic health, measured via deep-learning on CT scans, is linked to better immunotherapy outcomes in cancer patients.
- Higher thymic health correlates with reduced risks of progression and mortality in non-small cell lung cancer (NSCLC).
- Thymic health remains significant across varying levels of PD-L1 and tumor mutation burden.
- In the TRACERx study, thymic health was associated with T cell receptor diversity and immune-system signaling pathways.
- Findings suggest thymic health as a tumor-agnostic biomarker for immunotherapy efficacy, relevant across melanoma, breast, and renal cancers.
- Potential implications include improved patient stratification, treatment timing, and immune-rejuvenating strategies in immuno-oncology.