NeuroViOme: a viral orfeome collection for studies of neurodegenerative disease - PubMed
4 hours ago
- #ORFeome
- #Viral Pathogenesis
- #Neurodegenerative Diseases
- Neurodegenerative diseases like Alzheimer's, Parkinson's, ALS, and MS are a global health challenge with no cure.
- Viral infections may contribute to the onset and progression of these diseases through direct or immune-mediated mechanisms.
- Protein-protein interactions (PPIs) between viral and host proteins are crucial for viral replication and may disrupt host cell function, contributing to disease.
- NeuroViOme is introduced as a viral ORFeome resource for studying interactions between viral and host proteins in neurodegeneration.
- The collection includes protein-coding sequences from nine viruses linked to neurodegenerative processes, such as Enteroviruses, Herpesviruses, HERV-K, and JCPyV.
- NeuroViOme aims to support interactome mapping and functional genomics to understand viral contributions to neurodegenerative diseases.