Does ACE2 deficiency have a role in Parkinson's disease -exacerbated pulmonary fibrosis? - PubMed
3 hours ago
- #Parkinson's disease
- #ACE2
- #Pulmonary fibrosis
- ACE2 deficiency exacerbates Parkinson's disease (PD) symptoms like motor dysfunction and dopaminergic neuron loss, and worsens lung fibrosis with increased collagen deposition.
- Bioinformatics analysis identified 41 overlapping genes between PD and idiopathic pulmonary fibrosis (IPF), highlighting pathways involving downregulated FoxO1 and upregulated TNF, JAK1-STAT3, and AGE-RAGE.
- The study suggests ACE2 deficiency drives PD-exacerbated pulmonary fibrosis through FoxO1/TNF/JAK1-STAT3/AGE-RAGE pathways, proposing potential biomarkers and therapeutic candidates like Smilagenin and Fostamatinib.