HOP2-MND1 chaperones a diffusing DMC1-ssDNA complex to survey dsDNA for homology recognition during meiotic recombination - PubMed
5 hours ago
- #HOP2-MND1
- #DMC1
- #meiotic recombination
- HOP2-MND1 chaperones DMC1-ssDNA complex during meiotic recombination.
- DMC1-ssDNA presynaptic complex uses diffusion to search for homologous DNA.
- HOP2-MND1 enables homology recognition by codiffusing with the presynaptic complex.
- HOP2-MND1 clamps ssDNA-dsDNA junctions to maintain an expanded DNA bubble.
- DMC1 and HOP2-MND1 form a functional homology search unit.