FNDC4 Regulates TGF-β1-Induced Hepatic Stellate Cell Activation and Liver Fibrosis via the AMPK/YAP Pathway - PubMed
3 days ago
- #Liver Fibrosis
- #FNDC4
- #AMPK/YAP Pathway
- FNDC4 regulates TGF-β1-induced hepatic stellate cell (HSC) activation and liver fibrosis via the AMPK/YAP pathway.
- Circulating and hepatic FNDC4 levels inversely correlate with liver fibrosis severity in obesity-related MASLD.
- FNDC4 is predominantly expressed in hepatocytes and enhances HSC transdifferentiation, increasing mitochondrial activity and glycolysis.
- FNDC4 attenuates TGF-β1-induced collagen type I expression, apoptosis, and ROS production in HSCs while increasing MMP-1 and GATA4.
- FNDC4 inhibits TGF-β1-driven HSC migration by suppressing YAP expression and activation, downstream of AMPK.
- Reduced hepatic FNDC4 may contribute to persistent liver fibrosis in obesity-related MASLD.