Distinctive DNA sequence features define epigenetic longevity of inflammatory memory - PubMed
3 hours ago
- #memory persistence
- #inflammation
- #epigenetics
- Tissues retain memories of inflammation, enhancing sensitivity to future assaults.
- Epidermal stem cells in mice store lifelong epigenetic records of psoriasis-like skin flares.
- CpG dinucleotide density is identified as a major driver of memory persistence in chromatin dynamics.
- CpG-enriched sequences are essential for reinforcing accessibility across cellular generations.
- Memory persistence involves DNA demethylation, methylation-sensitive transcription factors, nucleosome disaffinity, and histone variant H2A.Z.
- DNA sequences orchestrate persistent poise, affecting tissue fitness upon recall.