TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease - PubMed
4 days ago
- #Diabetic Kidney Disease
- #Podocyte Injury
- #Exosomes
- TRIM27-controlled endothelium-derived exosomes are central to podocyte injury in diabetic kidney disease.
- High glucose and TGF-β1 stimulate human renal glomerular endothelial cells (HRGECs) to produce more exosomes, leading to podocyte injury.
- Inhibition of exosome secretion, TRIM27 knockdown, or miR-486-5p inhibition prevents HRGEC-induced podocyte injury.
- Injections of HRGEC-derived exosomes worsen podocyte injury and proteinuria in diabetic mice, reversible by miR-486-5p inhibitor.
- Endothelial-specific TRIM27 or miR-486-5p knockdown preserves kidney function and reduces podocyte injury in diabetic mice.
- Targeting exosomes may offer new therapeutic strategies for diabetic kidney disease.