An H3K4me3 reader recruits the positive transcription elongation factor B complex to facilitate transcription elongation in Arabidopsis - PubMed
3 days ago
- #H3K4me3
- #transcription elongation
- #P-TEFb
- H3K4me3 activates gene expression by promoting RNA Pol II pause-release and transcription elongation.
- RGSA1, an H3K4me3 reader, is essential for salicylic acid-induced gene transcription in Arabidopsis.
- RGSA1 binds to H3K4me3 via a cysteine-tryptophan domain and recruits P-TEFb to facilitate transcription elongation.
- The study suggests a conserved mechanism for transcription elongation across eukaryotes involving H3K4me3 readers and P-TEFb.