SREBP2 links ACSS2-dependent acetyl-CoA biosynthesis to metaboloepigenetic activation of hepatic stellate cells and liver fibrosis - PubMed
3 hours ago
- #ACSS2
- #liver fibrosis
- #SREBP2
- SREBP2 deletion in hepatic stellate cells (HSCs) or myofibroblasts reduces liver fibrosis in mice.
- SREBP2 activates ACSS2 transcription, which is necessary for acetyl-CoA production and histone acetylation.
- ACSS2 inhibition mitigates liver fibrosis, suggesting therapeutic potential for targeting this pathway.