Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation - PubMed
3 hours ago
- #antimicrobial resistance
- #insertion sequences
- #plasmids
- Plasmids are mobile genetic elements that spread antimicrobial resistance (AMR) genes in bacteria.
- Insertion sequences (IS) on plasmids, like IS1 in plasmid pOXA-48, disrupt genes to increase antibiotic resistance rates.
- Experimental and computational models show conjugative plasmids promote AMR via IS-mediated gene inactivation in bacterial communities.
- Genome database screening confirms IS-mediated gene inactivation is a widespread AMR evolution mechanism.
- Plasmids contribute to AMR both by spreading resistance genes and through IS-mediated gene disruption.