Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases - PubMed
3 hours ago
- #sleep disorders
- #neurodegenerative diseases
- #epidemiology
- Sleep disorders (SDs) are associated with an increased risk of neurodegenerative diseases (NDDs), with a hazard ratio of 1.32.
- The study included 30,032 participants with SDs and 147,321 without SDs from the UK Biobank cohort.
- SDs were linked to higher NDD risk regardless of treatment status, and specific SD subtypes also showed increased risk.
- Sleep behaviors like difficulty waking and daytime napping were associated with higher NDD risk in individuals with SDs.
- Incorporating SD subtype variables improved the performance and clinical utility of NDD prediction models.
- The findings highlight the potential of SDs and related behaviors as targets for early prevention strategies against NDDs.