β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer - PubMed
5 days ago
- #metabolism
- #CAR T cell
- #cancer therapy
- β-hydroxybutyrate (BHB) enhances CAR T cell function in cancer.
- BHB supports the TCA cycle, driving oxidative phosphorylation and energy generation in CAR T cells.
- Metabolic enhancement leads to improved CAR T cell proliferation, cytokine production, and tumor control.
- BHB induces transcriptional and epigenetic reprogramming, promoting an enhanced effector and metabolic profile.
- In healthy volunteers, BHB supplementation improved T cell oxygen consumption, mitochondrial membrane potential, and ATP production.
- BHB metabolite intervention is a promising strategy to improve adoptive T cell therapy against cancer.