Regenerative and Stem Cell-Based Therapies for Arthritis: Harnessing Mesenchymal Stem Cells, Exosomes, and Bioengineered Scaffolds for Functional Joint Repair - PubMed
3 hours ago
- #Stem Cell Therapy
- #Regenerative Medicine
- #Arthritis Treatment
- Arthritis, including osteoarthritis (OA) and rheumatoid arthritis (RA), is a major cause of chronic pain and disability globally.
- Current treatments focus on symptom relief rather than addressing cartilage and bone degeneration.
- Regenerative medicine offers new approaches using mesenchymal stem cells (MSCs), exosomes, and bioengineered scaffolds for joint repair.
- MSCs have differentiation potential and immunomodulatory effects that aid cartilage repair.
- MSC-derived exosomes provide a cell-free alternative with therapeutic benefits via bioactive cargo.
- Bioengineered scaffolds, combined with stem cells or exosomes, support tissue regeneration.
- Challenges include safety, standardization, scalability, and regulatory approval for these therapies.
- Emerging technologies like nanotechnology, AI, and gene editing could enhance personalized arthritis treatments.
- These innovations mark a shift from symptom management to biological repair in arthritis therapy.