Herpes simplex virus type 1 encephalitis: A prospective population-based cohort study - PubMed
4 hours ago
- #HSV-1
- #encephalitis
- #acyclovir
- Study investigates clinical characteristics and outcomes of HSV-1 encephalitis patients.
- Nationwide, prospective, population-based cohort study conducted in Denmark (2015-2023).
- 154 patients included, with mean annual incidence of 0.36/100,000.
- Common symptoms at admission: fever (79%) and confusion (78%).
- Median time to lumbar puncture: 21 hours; to acyclovir treatment: 24 hours.
- Delayed acyclovir (>6 hours after lumbar puncture) linked to higher mortality (RR 1.85).
- 6% of patients developed anti-NMDA receptor encephalitis post HSV-1 encephalitis.
- Early recognition of HSV-1 encephalitis remains challenging with high mortality rates.