Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes - PubMed
3 days ago
- #stress response
- #ribosome oligomerization
- #cryo-electron tomography
- Ribosomal RNA expansion segments (ES31Lb) mediate the oligomerization of inactive ribosomes in stressed mammalian cells, including neurons.
- Cryo-electron tomography (cryo-ET) revealed ribosome dimerization via homotypic interactions of ES31Lb, which is necessary and sufficient for disome formation.
- ES31Lb interactions provide a growth advantage and stress resistance to brain cells and are predicted to homodimerize in ~20% of chordates, including humans and chickens.
- Cryo-ET analysis of chicken tetrasomes showed an interaction between ES31Lb and ES9La, indicating flexible use of rRNA expansion segments in translation regulation.