Species-specific chromatin architecture and neurogenesis mediated by a human enhancer - PubMed
3 hours ago
- #neurogenesis
- #chromatin architecture
- #human evolution
- Human accelerated regions (HARs) contain human-specific variants, with about 50% acting as neurodevelopmental enhancers.
- Human HAR1984 promotes neurogenesis by influencing species-specific transcription and chromatin interactions.
- Knockin experiments show Hs-HAR1984 increases neurogenesis in chimpanzee organoids and mice, while Pt-HAR1984 reduces it in human organoids.
- HAR1984 forms chromatin loops with target genes ETV5 and TRA2B in human fetal brains, reduced in other species.
- Human-specific ETV5 binding auto-regulates HAR1984 enhancer activity, linking HARs to human cortical expansion.