Neuromodulation of swarming behavior in Caenorhabditis elegans: Insights into the conserved role of calsyntenins - PubMed
4 days ago
- #C. elegans
- #Calsyntenin
- #Swarming
- Collective behaviors in C. elegans are influenced by internal states and external cues.
- Swarming behavior occurs due to uncontrolled local population density increases, even with abundant food.
- The calsyntenin protein CASY-1 plays a key role in regulating swarming by modulating neuropeptide PDF signaling.
- casy-1 mutants exhibit impaired PDF-1 signaling and reduced serotonin pathway inhibition, leading to swarming.
- CASY-1's role in mechanosensory and foraging defects also contributes to the swarming phenotype.
- The study identifies a neuromodulatory pathway critical for swarming behavior in C. elegans.