Epigenetic remodeling in sarcoma promotes T-cell infiltration via modulation of the Hippo pathway - PubMed
10 hours ago
- #Epigenetics
- #Sarcoma
- #Immunotherapy
- H3K27ac is a key regulator of CD8+ T-cell infiltration in sarcomas.
- Entinostat increases H3K27ac, boosting CD8+ T-cell activity and recruitment.
- Immune effects occur via Hippo pathway switch: YAP1 suppression and VGLL3 induction.
- VGLL3/CD103 signatures predict anti-PD-1 response in sarcoma patients.
- Combining H3K27ac elevation with anti-PD-1 enhances T-cell killing in models.