Mechanistic Investigation of Exercise Interventions in Rodent Models of Alzheimer's Disease and Prospects for Clinical Translation - PubMed
4 hours ago
- #Neuroplasticity
- #Alzheimer's Disease
- #Exercise Intervention
- Exercise interventions in rodent models of Alzheimer's Disease (AD) show potential in reversing neuropathology.
- Key mechanisms include modulation of APP processing, Aβ production/clearance, and mitochondrial function restoration.
- Exercise attenuates neuroinflammation, enhances synaptic plasticity, and upregulates neurotrophic factors.
- Gut microbiota modulation through exercise promotes neuroimmune homeostasis and cognitive resilience.
- Identified genes (Tlr4, Cdc42, F13a1) play roles in neuroimmune regulation and cognitive protection.
- Proposed 'exercise-microbiota-brain' framework supports personalized therapeutic strategies for AD.
- Future studies should explore combining exercise with complementary interventions for clinical translation.