Activation of α7nAChR reduces inflammation and apoptosis, promoting muscle regeneration through the AKT-FOXO1 pathway - PubMed
19 hours ago
- #α7nAChR
- #Muscle Regeneration
- #AKT-FOXO1 Pathway
- Activation of α7nAChR reduces inflammation and apoptosis, promoting muscle regeneration via the AKT-FOXO1 pathway.
- Denervation decreases α7nAChR expression, increasing inflammation and apoptosis, which leads to muscle atrophy.
- Treatment with PNU120596 or electroacupuncture restores α7nAChR function and alleviates muscle atrophy.
- Targeting α7nAChR offers a promising therapeutic approach for muscle wasting after denervation.