Global prevalence, incidence, and years lived with disability (YLDs) of osteoarthritis: trends from 1990 to 2021 and projections to 2050 - PubMed
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- #global burden
- #osteoarthritis
- Global osteoarthritis (OA) burden increased from 1990 to 2021, with 607.0 million prevalent cases, 46.6 million incident cases, and 21.3 million YLDs in 2021.
- YLDs attributable to high BMI tripled from 1.45 million (1990) to 4.42 million (2021).
- Joinpoint regression showed peak increases in prevalence (2006–2009), incidence (2000–2009), and YLDs (2006–2009).
- Age, period, and cohort effects influenced OA risks, with earlier-born cohorts having higher risks.
- Female individuals, knee OA, and middle SDI quintile contributed most to prevalence.
- Population growth and aging were primary drivers of OA burden changes.
- Projections for 2050: 1.2 billion prevalent cases, 77.8 million incident cases, and 41.6 million YLDs.
- Study highlights need for improved OA management strategies and targeted interventions.