A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - PubMed
3 hours ago
- #keratinocytes
- #immunology
- #humoral-immunity
- Farnesyl pyrophosphate (FPP) is identified as an endogenous alarmin that enhances IgG antibody responses.
- FPP accumulation in keratinocytes is triggered by infection or ultraviolet irradiation via the mevalonate pathway.
- FPP binds to TRPV3, inducing Ca2+ influx and activating pathways that enhance IL-6 and CCL20 production.
- The FPP-TRPV3-IL-6/CCL20-GC axis potentiates pathogen-specific antibody production and germinal center responses.
- This signaling axis is hyperactivated in systemic lupus erythematosus (SLE) skin lesions and pathogen-infected mouse skin.
- The findings provide insights for developing vaccine adjuvants and potential SLE therapeutics.