Histone arginine demethylase JMJD7 promotes bone formation through regulating α-Ketoglutarate metabolism - PubMed
10 hours ago
- #Epigenetics
- #Metabolism
- #Osteoporosis
- JMJD7 loss is linked to osteoporosis in human biopsies and knockout mice.
- Female Jmjd7 knockout mice show osteoporosis and visceral adiposity.
- Jmjd7 deletion promotes H3R2me1 enrichment and suppresses osteogenic differentiation.
- Jmjd7 loss shifts metabolism to anaerobic glycolysis, reducing α-KG production.
- α-KG supplementation reverses epigenetic repression and improves bone formation.