γδTreg/γδTh17 Cell Imbalance Drives Xanthine-Mediated Metabolic Dysfunction in Restraint Stress-Induced Anxiety-Like Behavior - PubMed
3 hours ago
- #anxiety-like behavior
- #γδT17/γδTreg balance
- #metabolome
- Chronic restraint stress (RS) induces anxiety-like behavior in mice, linked to γδT17/γδTreg cell imbalance.
- γδT17 cells increase while γδTreg cells decrease in RS mice, affecting anxiety behavior.
- Depletion of γδT17 cells with αIL-17 antibody reduces anxiety-like behavior, whereas γδTreg depletion worsens it.
- Metabolomic changes in RS mice highlight alterations in purine and nucleotide metabolism, notably increased xanthine and hypoxanthine.
- Exogenous xanthine exacerbates neuronal damage in RS mice, crossing the blood-brain barrier and accumulating in the brain.
- The study identifies a γδT17/γδTreg-xanthine axis as a novel link between immune dysregulation, metabolic changes, and anxiety-like behavior.