Ginsenoside compound K inhibited the gelation of GGGGCC repeats and regulated co-aggregation with arginine-rich poly-dipeptides in C9orf72-related ALS - PubMed
3 hours ago
- #Ginsenoside CK
- #Neurodegeneration
- #ALS/FTD
- Ginsenoside compound K (CK) inhibits gelation of GGGGCC repeats in C9orf72-related ALS/FTD.
- CK reduces co-aggregation of RNA and arginine-rich poly-dipeptides via electrostatic interactions.
- CK preferentially interacts with G-quadruplex monomers, preventing toxic RNA foci formation.
- Study suggests potential therapeutic application of ginsenoside in neurodegenerative diseases.