MST1 promotes microglial pyroptosis and neuroinflammation in alzheimer's disease by regulating the novel DPP8/NLRP1/Caspase-1/GSDMD-N axis - PubMed
8 days ago
- #Alzheimer's disease
- #Microglia
- #Neuroinflammation
- MST1 promotes microglial pyroptosis and neuroinflammation in Alzheimer's disease (AD).
- MST1 regulates the DPP8/NLRP1/Caspase-1/GSDMD-N axis, contributing to AD progression.
- Knocking down MST1 in 5xFAD mice improved cognitive deficits and reduced neuroinflammation.
- MST1 knockdown suppressed microglial activation and pyroptosis, mitigating neuroimmune inflammation.
- Targeting MST1 is proposed as a therapeutic strategy to halt AD progression.