Proteomics and metabolomics biomarkers for predicting the onset and progression of diabetic complications: A systematic review and bioinformatics integration - PubMed
7 hours ago
- #diabetic complications
- #biomarkers
- #proteomics metabolomics
- Systematic review integrates proteomics and metabolomics to identify biomarkers for diabetic complications.
- Review includes 67 cohort and 41 cross-sectional studies with 73,580 participants (mainly T2D).
- Identifies 275 metabolites and 363 proteins as predictive biomarkers from serum/plasma and urine.
- Key pathways: lipoprotein metabolism (macrovascular), complement/coagulation (nephropathy), VEGFA-VEGFR2 (retinopathy), receptor-mediated endocytosis (neuropathy).
- Biomarkers show promise for early detection and risk stratification but require prospective validation.