Hepatoprotective potential of anthocyanins from purple highland barley bran against non-alcoholic fatty liver disease through gut-liver axis - PubMed
4 days ago
- #Anthocyanins
- #NAFLD
- #Gut-liver axis
- Anthocyanins from purple highland barley bran show hepatoprotective effects against non-alcoholic fatty liver disease (NAFLD).
- PAE (purified anthocyanin-rich extract) inhibits pancreatic lipase and cholesteryl esterase activities by over 60%.
- PAE reduces hepatic weight, total glyceride (TG), and total cholesterol (TC) in high-fat diet (HFD)-induced NAFLD models.
- PAE improves oxidative stress and inflammation by activating the Nrf2 pathway and inhibiting the p38 MAPK pathway.
- PAE enhances intestinal barrier function by increasing mucus thickness and goblet cell numbers.
- PAE alters colon metabolic profiles, impacting flavonoid biosynthesis and amino acid biosynthesis pathways.
- The study suggests PAE mitigates NAFLD via the gut-liver axis.