Repeated low-level red light modulates retinal metabolic alterations in lens-induced myopic chicks - PubMed
5 hours ago
- #myopia control
- #red-light therapy
- #retinal metabolomics
- Repeated low-level red light (RLRL) therapy significantly reduced myopic shift and axial elongation in lens-induced myopic chicks by 50.6% and 43.3%, respectively.
- RLRL inhibited myopia-associated choroidal thinning without causing detectable retinal damage.
- Metabolomic analysis showed RLRL reversed dysregulation in amino acid and lipid metabolism, upregulating neuroprotective and visual function metabolites while downregulating inflammatory and vascular dysregulation markers.
- qPCR validation indicated RLRL reduced inflammation-related genes (PTGS2 and IL-6) and increased NOS3 expression, suggesting restoration of nitric oxide signaling.
- The protective mechanism involves enhancing mitochondrial energy metabolism, suppressing pro-inflammatory pathways, and preserving choroidal thickness.