Association of admission serum potassium levels with mortality according to renal function in coronary artery disease: a prospective cohort study - PubMed
3 days ago
- #Renal function
- #Serum potassium
- #Coronary artery disease
- Study explores the association between admission serum potassium levels and mortality in coronary artery disease (CAD) patients, stratified by renal function.
- Renal function was categorized into normal, mildly decreased, and impaired based on estimated glomerular filtration rate (eGFR).
- All-cause mortality within 3 years was the outcome, observed in 4.7% of 7739 patients from a multicenter registry.
- In normal renal function, a U-shaped mortality curve was observed, but potassium levels were not significantly associated with mortality risk.
- In mildly decreased renal function, higher potassium levels (4.6-5.0 mmol/L and >5.0 mmol/L) were linked to increased mortality risk.
- In impaired renal function, potassium levels >5.0 mmol/L were associated with higher mortality risk, though the U-shaped curve flattened.
- A significant interaction was found between potassium levels and eGFR, highlighting the need to consider renal function when assessing mortality risk related to serum potassium in CAD.
- The study emphasizes the independent association of elevated potassium levels with increased mortality in patients with mildly decreased renal function.