cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells - PubMed
a day ago
- #NK cells
- #Leukemia stem cells
- #DNA damage response
- PARP1 inhibition in leukemia stem cells (LSCs) induces NKG2D ligand expression via DNA damage response activation.
- Activation of cGAS/STING pathway by DNA damage leads to upregulation of NKG2D ligands in LSCs.
- STING and IRF3 are essential for NKG2D ligand regulation in LSCs under DNA damage conditions.
- Enhanced NK cell cytotoxicity against LSCs is mediated by NKG2D ligand upregulation.
- The study highlights the role of cGAS/STING/TBK1/IRF3 signaling in immune surveillance against leukemia.