DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles - PubMed
10 hours ago
- #lipid nanoparticle
- #pancreatic neuroendocrine tumor
- #DNA repair enzyme
- Developed lipid nanoparticles modified with Octreotide to target somatostatin receptors for co-delivery of Temozolomide and MGMT-siRNA to overcome drug resistance in pancreatic neuroendocrine tumors.
- The LOTR system enhanced therapeutic efficacy by sensitizing tumors to Temozolomide, lowering drug resistance, and reducing off-target effects in vitro and in vivo.
- This strategy addresses limitations of Temozolomide due to MGMT-mediated resistance and systemic toxicity, offering a promising treatment for advanced pancreatic neuroendocrine tumors.