Structural basis for prostaglandin and drug transport via SLCO2A1 - PubMed
3 hours ago
- #drug transporters
- #SLCO2A1
- #prostaglandin transport
- SLCO2A1 (OATP2A1) is an organic anion-transporting polypeptide transporter that regulates the distribution of eicosanoids (prostaglandins and thromboxanes) and nonsteroidal anti-inflammatory drugs (NSAIDs) in the body.
- Cryogenic electron microscopy structures of SLCO2A1 bound to prostaglandins and four medications (for inflammation, chronic asthma, and Parkinson's disease) reveal substrate recognition mechanisms.
- Molecular dynamics and cellular assays provide insights into the molecular basis of prostaglandin and drug recognition by SLCO2A1.
- The study elucidates substrate selection and subfamily adaptation within the SLCO superfamily, aiding drug and metabolite transporter research.