Adhesion G protein-coupled receptors - PubMed
4 hours ago
- #Cell Signaling
- #Adhesion GPCRs
- #Therapeutic Targeting
- Adhesion G protein-coupled receptors (aGPCRs) are a distinct group within the GPCR superfamily.
- In 2015, the Adhesion GPCR Consortium published a comprehensive review and established unified nomenclature.
- Significant progress has been made in understanding aGPCRs' biology, molecular architecture, signaling, and roles in health and disease.
- This review summarizes current knowledge, methodological approaches, model systems, and therapeutic targeting opportunities.
- aGPCRs are versatile cell-surface proteins integrating structural, biochemical, and physiological functions.
- The review connects basic biology with translational applications across multiple scientific disciplines.