The circTIMP2/miR-106a/TIMP2 tumor-suppressive axis versus tumor-derived exosomal counteraction in gastric cancer - PubMed
5 hours ago
- #CircRNA
- #Exosomes
- #Gastric cancer
- CircTIMP2 is significantly downregulated in gastric cancer, while miR-106a is upregulated, leading to TIMP2 downregulation.
- CircTIMP2 acts as a competitive endogenous RNA (ceRNA) by sponging miR-106a, releasing TIMP2 and forming a tumor-suppressive feedback loop.
- Overexpression of circTIMP2 inhibits malignant behaviors of gastric cancer cells and suppresses tumor growth via the Wnt/β-catenin pathway.
- Tumor-derived exosomes counteract circTIMP2's suppressive effects by inhibiting TIMP2 and reactivating Wnt/β-catenin signaling, promoting tumor progression.
- The study highlights a novel circRNA-mediated regulatory axis in gastric cancer and suggests potential therapeutic targets involving exosome modulation.