ZFP148 is a transcriptional repressor of cytolytic effector CD8+ T cell differentiation - PubMed
4 hours ago
- #immunology
- #transcription factors
- #cancer therapy
- ZFP148 is a transcriptional repressor that inhibits cytolytic effector CD8+ T cell differentiation.
- ZFP148 deficiency increases effector cells and reduces exhaustion during chronic viral infection.
- ZFP148 limits chromatin accessibility for effector-driving factors and represses KLF2 expression.
- Ablation of ZFP148 in CD8+ T cells synergizes with PD-1 blockade to improve tumor control in mice.
- Lower ZNF148 expression in tumor-infiltrating CD8+ T cells correlates with better immunotherapy response in cancer patients.